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Adrafinil: effects on
behavior and cognition in aged canines.
Siwak CT, Callahan H, Milgram NW
Institute of Medical Science, University of Toronto, Canada.
Prog Neuropsychopharmacol Biol Psychiatry
2000 Jul;24(5):709-26
ABSTRACT
1. Adrafmil is a novel vigilance promoting agent developed in France by Louis
Lafon Laboratories.
2. Adrafinil causes increased locomotion without producing
stereotypical activity in canines tested in an open field.
3. The
effectiveness of a single treatment is long-lasting, and the effectiveness
persists over repeated treatments.
4. Acquisition of a size discrimination
problem is enhanced by adrafinil. This may be linked to performance
motivation.
5. Adrafinil causes a long-lasting increase in high frequency
electroencephalographic activity recorded from cortical electrodes. 6. These
results indicate that adrafinil is novel behavioral stimulant with cognitive
enhancing potential. The underlying mechanisms of action are still unknown.
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